%0 Journal Article
%T Comparative Efficacy of Statins for Prevention of Contrast
%A Haibin Xu
%A Jie Chen
%A Jin Dai
%A Wei Mao
%A Xiaoming Xu
%A Xinbin Zhou
%A Yuangang Qiu
%A Zhijun Wang
%J Angiology
%@ 1940-1574
%D 2019
%R 10.1177/0003319718801246
%X Contrast-induced acute kidney injury (CI-AKI) is a common complication of iodinated contrast medium administration during cardiac catheterization. Statin treatment has been shown to be associated with reduced risk of CI-AKI; however, the results are inconsistent, especially for patients with chronic kidney disease (CKD). Thus, we conducted a network meta-analysis to evaluate the effects of statins in the prevention of CI-AKI. We systematically searched several databases (including, Embase, PubMed, the Cochrane Library, and ClinicalTrials.gov) from inception to January 31, 2018. The primary outcome was occurrence of CI-AKI in patients with CKD undergoing cardiac catheterization. Both pairwise and network meta-analysis were performed. Finally, 21 randomized controlled trials with a total of 6385 patients were included. Results showed that statin loading before contrast administration was associated with a significantly reduced risk of CI-AKI in patients with CKD undergoing cardiac catheterization (odds ratio: 0.46; P < .05). Atorvastatin and rosuvastatin administered at high dose may be the most effective treatments to reduce incidence of CI-AKI, with no difference between these 2 agents
%K statins
%K contrast-induced acute kidney injury
%K chronic kidney disease
%K network meta-analysis
%U https://journals.sagepub.com/doi/full/10.1177/0003319718801246