%0 Journal Article
%T Do Outcomes of Osteochondral Allograft Transplantation Differ Based on Age and Sex? A Comparative Matched Group Analysis
%A Brian J. Cole
%A Eric J. Cotter
%A Rachel M. Frank
%A Sarah Poland
%A Simon Lee
%J The American Journal of Sports Medicine
%@ 1552-3365
%D 2018
%R 10.1177/0363546517739625
%X The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed. To determine clinical outcomes for male and female patients aged ¡Ý40 years undergoing OCA compared with a group of patients aged <40 years. Cohort study; Level of evidence, 3. A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted. The reoperation rate, failure rate, and patient-reported outcome scores were reviewed. All outcomes were compared between patients aged <40 or ¡Ý40 years, with subgroup analyses conducted based on patient sex. Failure was defined as revision OCA, conversion to knee arthroplasty, or gross appearance of graft failure at second-look arthroscopic surgery. Descriptive statistics, Fisher exact or chi-square testing, and Mann-Whitney U testing were performed, with P < .05 set as significant. A total of 170 patients (of 212 eligible patients; 80.2% follow-up) who underwent OCA with a mean follow-up of 5.0 ¡À 2.7 years (range, 2.0-15.1 years) were included, with 115 patients aged <40 years (mean age, 27.6 ¡À 7.3 years; 58 male, 57 female) and 55 patients aged ¡Ý40 years (mean age, 44.9 ¡À 4.0 years; 33 male, 22 female). There were no differences in the number of pre-OCA procedures between the groups (P = .085). There were no differences in the reoperation rate (<40 years: 38%; ¡Ý40 years: 36%; P = .867), time to reoperation (<40 years: 2.12 ¡À 1.90 years; ¡Ý40 years: 3.43 ¡À 3.43 years; P = .126), or failure rate (<40 years: 13%; ¡Ý40 years: 16%; P = .639) between the older and younger groups. Patients in both groups demonstrated significant improvement in Lysholm (both: P < .001), International Knee Documentation Committee (IKDC) (both: P < .001), Knee Injury and Osteoarthritis Outcome Score (KOOS) (both: P < .001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (both: P < .001), and Short Form¨C12 (SF-12) physical (both: P < .001) scores compared with preoperative values. Patients aged ¡Ý40 years demonstrated significantly higher KOOS symptom (P = .015) subscores compared with patients aged <40 years. There were no significant differences in the number of complications, outcome scores, or time to failure between the sexes. In patients aged <40 years, female patients experienced failure significantly more quickly than male patients (P = .039). In contrast, in patients aged ¡Ý40 years, male patients experienced failure significantly more quickly than female patients (P = .046). This study provides evidence
%K knee
%K articular cartilage
%K meniscus
%K female athlete
%K aging athlete
%U https://journals.sagepub.com/doi/full/10.1177/0363546517739625