%0 Journal Article
%T Discriminative ability and clinical utility of the Timed Up and Go (TUG) in identifying falls risk in people with multiple sclerosis: a prospective cohort study
%A Chris McGuigan
%A Gillian Quinn
%A Laura Comber
%A Rose Galvin
%A Susan Coote
%J Clinical Rehabilitation
%@ 1477-0873
%D 2019
%R 10.1177/0269215518793481
%X To investigate discriminative ability and clinical utility of the Timed Up and Go under single- and dual-task conditions between fallers and non-fallers in multiple sclerosis (MS). Prospective cohort study. Neurology service in a tertiary hospital. Participants were 101 people with MS and Expanded Disability Status Scale score of 3¨C6.5. One participant withdrew after the baseline assessment, and hence the data were analysed for 100 participants. No specific intervention. Timed Up and Go and Timed Up and Go-Cognitive. Three-month prospective diaries recorded falls. Mean age was 52.6 (SD 10.7) and 66 were female. Majority of the participants had progressive MS (72) and 73 used a walking aid; 56 participants recorded 791 falls. The area under the receiver operating characteristic curve values for Timed Up and Go and Timed Up and Go-Cognitive in distinguishing fallers (person with £¿1 fall) from non-fallers are 0.60 and 0.57, respectively, and in distinguishing multiple fallers (£¿2 falls) the values are 0.46 and 0.43. A Timed Up and Go score of £¿9£¿seconds has a sensitivity of 0.82 and a specificity of 0.34 to identify fallers and a sensitivity of 0.79 and a specificity of 0.27 to identify multiple fallers. A Timed Up and Go-Cognitive score of £¿11£¿seconds has a sensitivity of 0.77 and a specificity of 0.30 to identify fallers and a sensitivity of 0.71 and a specificity of 0.26 to identify multiple fallers. The Timed Up and Go and Timed Up and Go-Cognitive do not demonstrate sufficient clinical utility or discriminative ability for assessing falls risk in MS
%K Multiple sclerosis
%K accidental falls
%K risk
%K Timed Up and Go
%U https://journals.sagepub.com/doi/full/10.1177/0269215518793481