%0 Journal Article
%T Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma
%A Chunhua Wang
%A Chunmei Chen
%A Quan Chen
%A Rui Wang
%A Saizhen Wang
%A Shuqian Lin
%A Songsheng Shi
%J Integrative Cancer Therapies
%@ 1552-695X
%D 2018
%R 10.1177/1534735418762537
%X Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma. This study was designed to identify and characterize the antitumor action and influence of immune system of GL-PS in glioma-bearing rats. Results showed that GL-PS increased the concentration of serum interleukin-2, tumor necrosis factor-¦Á, and interferon-¦Ã, and enhanced the cytotoxic activity of natural killer cells and T cells, promoting the functional maturation of dendritic cells, thus resulting in the inhibition of glioma growth and prolonged survival of rats. Therefore, GL-PS may be potentially useful as part of the treatment regimen to regulate host immune responses and increase the antitumor effects of immunotherapy for glioma
%K Ganoderma lucidum polysaccharides
%K glioma
%K antitumor
%K immunomodulation
%K tumor-bearing rat model
%U https://journals.sagepub.com/doi/full/10.1177/1534735418762537