%0 Journal Article
%T Mussel
%A Guihua Meng
%A Hao Wang
%A Jianning Wu
%A Lin Cui
%A Qian Wang
%A Xiaoman Han
%A Xuhong Guo
%A Zhiyong Liu
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328218810552
%X All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-¦Ã-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-¦Ã-poly glutamic acid (CSE-PD) hydrogel. The two hydrogels are prepared by applying an enzyme-catalyzed crosslinking means in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structures were characterized through 1H-NMR and FT-IR. In conclusion, both PBS-PD and CSE-PD hydrogels exhibit superior tissue adhesion properties, and remarkable anti-infection quality. In addition, these two hydrogels manifest prominent hemostatic efficiency. The bio adhesion performance can achieve 30 kPa, meanwhile the CSE-PD hydrogels show good germicidal properties, and the antibacterial rate can reach 98%. The hydrogels could reduce blood loss without any obvious side effect, and present a new prospect in the field of hemostasis rapidly
%K Bio-inspiration
%K adhesive hydrogels
%K hemostasis
%K anti-microbial
%K functional
%K composite materials
%U https://journals.sagepub.com/doi/full/10.1177/0885328218810552