%0 Journal Article
%T Bioactive poly(¦Å
%A Anmin Zhou
%A Wen-song Tan
%A Yan Zhou
%A Zhaoyang Ye
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328218825371
%X Microparticles with porous structure can be applied as microcarriers for both cell culture and tissue regeneration. While well-controlled pore structure represents a critical challenge to be achieved. In the present study, in order to develop microcarriers for cell culture, a series of poly(¦Å-caprolactone) microspheres were fabricated with varied macroporous structures. Poly(¦Å-caprolactone) microspheres were prepared via the integration of the emulsion/solvent evaporation and particle leaching mechanisms. Particularly, by adjusting poly(¦Å-caprolactone) concentration and the ratio between the porogen paraffin and poly(¦Å-caprolactone), the microspheres with the pore size of 25.6¨C84.0£¿¦Ìm and the porosity of 57.4¨C75.5% were obtained. Further, the microspheres were subjected to alkaline hydrolysis, followed by surface coating with hydroxyapatite. These porous poly(¦Å-caprolactone) microspheres with surface modification well supported the adhesion and growth of human fibroblasts. Together, bioactive poly(¦Å-caprolactone) microspheres with controlled pore structure are potential to be applied in cell culture and tissue regeneration
%K Poly(¦Å-caprolactone)
%K microspheres
%K pore structure
%K cell culture
%U https://journals.sagepub.com/doi/full/10.1177/0885328218825371