%0 Journal Article
%T Zeolite
%A Hao Chen
%A Jie Fan
%A Liping Xiao
%A Lisha Yu
%A Xiaoqiang Shang
%A Yun Long Li
%A Zhugang Wang
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328219832380
%X Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22£¿¡À£¿3 s vs. >600 s) and in vivo (4.5 min vs. >60 min) compared to control in coagulation factor VIII deficiency bleeding model. Therefore, in situations of surgical operation or accidental injury, this effective and ready-to-use haemostatic agent may provide rapid haemostasis for haemophilia A patients
%K Zeolite-fibrin clot composite
%K haemostatic agent
%K haemophilia A
%U https://journals.sagepub.com/doi/full/10.1177/0885328219832380