%0 Journal Article
%T Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus
%A Caroline Silveira
%A Federico Giannitti
%A Francisco A. Uzal
%A Franklin Riet-Correa
%A Juan Arbiza
%A Leticia Maya
%A Mark L. Anderson
%A Mart¨ªn Fraga
%A Melissa Mac¨ªas-Rioseco
%A Rodney Colina
%A Santiago Mirazo
%J Veterinary Pathology
%@ 1544-2217
%D 2019
%R 10.1177/0300985818798117
%X Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing
%K abortion
%K bovine parainfluenza virus-3
%K fetus
%K immunohistochemistry
%K reproductive pathology
%K Paramyxoviridae
%K Respirovirus
%K RT-PCR
%U https://journals.sagepub.com/doi/full/10.1177/0300985818798117