%0 Journal Article
%T Analytical High
%A Alan K. Dozier
%A Eileen Birch
%A Joseph Fernback
%A Krishnamurthy Mahalingam
%A Lawrence Drummy
%A Michael T. Tseng
%A Robert A. Yokel
%A Uschi M. Graham
%J Toxicologic Pathology
%@ 1533-1601
%D 2018
%R 10.1177/0192623317737254
%X This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure. These advanced analytical electron microscopy methods were applied to elucidate the organ-specific cellular and subcellular fate of nanoceria after its uptake. Nanoceria is bioprocessed differently in the spleen than in the liver
%K bioprocessing
%K ions
%K liver
%K nanoceria
%K nanoparticles
%K spleen
%K transformation
%U https://journals.sagepub.com/doi/full/10.1177/0192623317737254