%0 Journal Article
%T MRI ultrasound fusion biopsy in prostate cancer detection: Are randomized clinical trials reproducible in everyday clinical practice?
%A Alessandro Sciarra
%A Andrea Fasulo
%A Francesco Maria Drudi
%A Mauro Ciccariello
%A Stefano Salciccia
%A Susanna Cattarino
%A Valerio Cantisani
%A Valerio Forte
%J Urologia Journal
%@ 1724-6075
%D 2019
%R 10.1177/0391560319834490
%X The aim of this study was to evaluate the performance of multiparametric magnetic resonance imaging (mpMRI)¨Cultrasound (US) fusion-targeted biopsies (TB) in men with primary and repeated biopsies comparing the cancer detection rate (CDR) of random biopsies (RB)£¿+ TB versus only TB. The present study is a real-life study on patients with primary and prior negative prostate biopsies with suspicious PCa. A total of 130 men with prostate-specific antigen (PSA) value£¿>2.5£¿ng/dL and/or abnormal digital rectal examination (DRE) were included in the study and subjected to mpMRI. Patients with£¿>2 previous biopsies and/or with£¿£¿3 suspected lesions on MRI and/or prostate imaging-reporting and data system (PIRADS) value£¿£¿4 (n:30 pts) were subjected only to TB on the areas indicated by mpMRI. All the other patients (n:70 pts) were subjected to standard random laterally directed 10-core plus TB on the areas indicated by mpMRI. The overall CDR was 53% (53/100). In relation to PIRADS score, the overall CDR was 0, 40% (12/30), 56.83% (29/51), and 84% (11/13) for PIRADS 2, 3, 4, and 5, respectively. According to biopsy modality, CDR for RB£¿+£¿TB was 50% (35/70) and CDR for TB was 60% (18/30) with a p-value of 0.3632. MRI¨CUS fusion biopsy is associated with a high CDR of clinically significant PCa (csPCa). MRI¨CUS fusion biopsy could be a reasonable approach in patients with previous negative biopsy and high PIRADS score on MRI, to ensure a high CDR of csPCa and to reduce the diagnosis of clinically insignificant tumors
%K Prostate cancer
%K multiparametric magnetic resonance
%K random biopsy
%K targeted biopsy
%K clinically significant tumor
%U https://journals.sagepub.com/doi/full/10.1177/0391560319834490