%0 Journal Article
%T 223Ra
%A Azzurra Farnesi
%A Carlo Gobitti
%A Claudia Cianci
%A Duccio Volterrani
%A Elda Lamaj
%A Elisa Lodi Rizzini
%A Eugenio Borsatti
%A Fabio Monari
%A Francesco Massari
%A Giuseppe Boni
%A Luca Galli
%A Lucia Fratino
%A Pietro Ghedini
%A Roberto Bortolus
%A Sara Mazzarri
%A Stefano Fanti
%A Valeria Dionisi
%J Tumori Journal
%@ 2038-2529
%D 2018
%R 10.1177/0300891618765571
%X Radium-223 (223Ra) chloride, an alpha emitter, has been shown to improve overall survival (OS) and pain control, and to delay skeletal-related events, in patients with castration-resistant prostate cancer (CRPC) and bone metastases. Our retrospective observational study presents the first Italian experience on the efficacy and safety of 223Ra therapy in routine clinical practice. A total of 83 patients with metastatic CRPC were treated with 223Ra at 3 Italian centers between August 2013 and August 2016. 223Ra-chloride (55 kBq/kg) was administered every 4 weeks for a total of 6 cycles. Primary endpoints were OS and progression-free survival (PFS). Secondary endpoints included toxicity, pain evaluation using numeric rating scale (NRS), symptomatic skeletal-related events and biomarkers response. Patients had a median age of 75 (range 53¨C89) years. The majority of men showed a Gleason score of 7, 8, or 9. Forty-one patients completed 6 treatment cycles; 33 stopped treatment before completing 6 cycles. Nine were still receiving therapy at the time of data collection. At the end of therapy, NRS pain scores significantly improved (p < .000001). OS was a mean of 10.1 months, while median OS had not been attained. According to Kaplan-Meier estimation, OS and PFS were 17.5 and 7.7 months, respectively. There was a significant correlation between OS and PFS with the number of 223Ra cycles; patients receiving all 6 cycles experienced the major benefit from the therapy. 223Ra was well-tolerated. 223Ra alpha therapy is an important therapeutic option for men with CRPC and symptomatic skeletal metastases
%K Brachytherapy
%K hormone-refractory prostate cancer
%K neoplasm metastasis
%K radium
%U https://journals.sagepub.com/doi/full/10.1177/0300891618765571