%0 Journal Article
%T Relevance of testicular histopathology on prediction of sperm retrieval rates in case of non
%A Alessandro Natali
%A Andrea Cocci
%A Candida De Carlo
%A Elisabetta Micelli
%A Gabriella Nesi
%A Gianmartin Cito
%A Luciana Criscuoli
%A Marco Carini
%A Maria E Coccia
%A Pier A Della Camera
%A Rita Picone
%A Sara Dabizzi
%A Sergio Serni
%A Simone Morselli
%J Urologia Journal
%@ 1724-6075
%D 2018
%R 10.1177/0391560318758940
%X The aim of our research was to establish the relevance of testicular histopathology on sperm retrieval after testicular sperm extraction in patients with non-obstructive azoospermia and in patients with obstructive azoospermia, who already underwent a previous failure testicular fine needle aspiration. We evaluated a total of 82 azoospermic men, underwent testicular sperm extraction, referring to the Assisted Reproductive Technology Centre of the University of Florence, Italy between January 2008 and March 2017. A general and genital physical examination, scrotal and trans-rectal ultrasound, semen analysis, hormone measurements, including follicle-stimulating hormone, luteinizing hormone and total testosterone, were collected. Successful sperm retrieval was obtained in 36 men of total (43.9%). Successful sperm retrieval was 29.5% in non-obstructive azoospermia patients, while men with obstructive azoospermia, who, underwent a previous failure testicular fine needle aspiration, had sperm retrieval in 86% of cases. Mean luteinizing hormone was 6.55£żIU/L, total testosterone 4.70£żng/mL, right testicular volume 13.7£żmL and left testicular volume 13.6£żmL. Mean Follicle-stimulating hormone was 13.45£żIU/L in patients with negative sperm retrieval and 8.18£żIU/L in men with successful sperm retrieval. According to histology, 20.7% had normal spermatogenesis, 35.3% hypospermatogenesis, 35.3% maturation arrest and 8.5% Sertoli cell-only syndrome. Successful sperm retrieval was 88.2% in patients with normal spermatogenesis, 24.1% in the maturation arrest group and 48.27% in patients with hypospermatogenesis, while negative sperm retrieval was reported in Sertoli cell-only syndrome patients. Seven cases with maturation arrest showed a successful sperm retrieval. Testicular histopathology after testicular sperm extraction offers important information on prediction of sperm retrieval and can guide the surgeon in choosing the more suitable therapeutic practice
%K Azoospermia
%K male infertility
%K testicular sperm extraction
%K testicular histology
%K sperm retrieval
%U https://journals.sagepub.com/doi/full/10.1177/0391560318758940