%0 Journal Article
%T Clinical presentation of optic neuritis with autoantibodies anti
%A Jean-Baptiste Ducloyer
%A Laure Michel
%A Pierre Lebranchu
%A Sandrine Wiertlewski
%J European Journal of Ophthalmology
%@ 1724-6016
%D 2019
%R 10.1177/1120672118784797
%X Myelin oligodendrocyte glycoprotein autoantibodies are associated with certain optic neuritis. Little data are known about the specificity of the initial ophthalmologic presentation. A monocentric retrospective study (2013每2017) of all patients diagnosed with myelin oligodendrocyte glycoprotein+ optic neuritis in a tertiary ophthalmologic unit was conducted. The primary objective was to define the clinical ophthalmologic description of the first episode. The secondary objective was to evaluate the evolution and final diagnosis. A total of nine patients were included. There was no female predominance (sex ratio f/mˋ=ˋ0.8). At the first optic neuritis episode, the average age was 39.3ˋyears (17每67ˋyears, standard deviation: 18.4). Initial visual acuity was low (+1.07logMAR, standard deviation: 0.77); 5 eyes out of 15 had visual acuity +2logMAR or worse. Optic neuritis was mostly painful (8/9) and bilateral (6/9) but asymmetric. Optic disk swelling was reported in 9/15 eyes and 7/9 patients and was significantly associated with lower visual acuity in the acute phase (+1.46logMAR, standard deviation: 0.67 vs +0.5, standard deviation: 0.55; pˋ=ˋ0.03). After a mean observation period of 3.3ˋyears (0.6每9.4ˋyears, standard deviation: 3.4), median visual acuity was 0.05logMAR. All five patients were followed up for more than 1ˋyear (5.4ˋyears, standard deviation: 3.2) had 3每8 relapses (mean: 4.4, standard deviation: 2.1; annualized relapse rate: 1.2, standard deviation: 0.9). Final diagnosis was chronic relapsing idiopathic optic neuritis (nˋ=ˋ4), clinically isolated optic neuritis (nˋ=ˋ3), and neuromyelitis optica spectrum disorder aquaporin 4每 (nˋ=ˋ2). Myelin oligodendrocyte glycoprotein+ optic neuritis has an atypical clinical presentation compared with multiple sclerosis and neuromyelitis optica spectrum disorder aquaporin 4+. Its evolution is closer to neuromyelitis optica spectrum disorder aquaporin 4+, with a better visual outcome
%K Aquaporin-4 antibodies (AQP4-IgG
%K NMO-IgG)
%K Devic＊s neuromyelitis optica
%K myelin oligodendrocyte glycoprotein autoantibodies
%K neuromyelitis optica spectrum disorder
%K optic neuritis
%U https://journals.sagepub.com/doi/full/10.1177/1120672118784797