%0 Journal Article %T External accelerated partial breast irradiation for ductal carcinoma in situ: long %A Carlotta Becherini %A Donato Casella %A Icro Meattini %A Isacco Desideri %A Jacopo Nori %A Livia Marrazzo %A Lorenzo Livi %A Lorenzo Orzalesi %A Luis Jose Sanchez %A Marco Bernini %A Pietro Garlatti %A Silvia Nesi %A Simonetta Bianchi %A Stefania Pallotta %A Vieri Scotti %J Tumori Journal %@ 2038-2529 %D 2019 %R 10.1177/0300891618811278 %X For a long time, accelerated partial breast irradiation (APBI) effectiveness for ductal carcinoma in situ (DCIS) has been debated, due to conflicting published results. Recent encouraging data from phase 3 trials reopened new perspectives for this radiation approach. The aim of the present study was to analyze the long-term efficacy and safety results of the series of patients with DCIS enrolled in the APBI arm of the APBI-IMRT-Florence phase 3 trial (NCT02104895). Patients were treated in a phase 3 randomized trial comparing whole breast irradiation (50 Gy in 25 fractions to the whole breast, plus 10 Gy in 5 fractions to the tumor bed) to APBI (30 Gy in 5 nonconsecutive fractions) using the intensity-modulated radiotherapy technique. Overall, 22 patients were treated in the APBI arm. Median age was 62 years (mean 59; range 42每75 years). At a median follow-up of 9.2 years (mean 8.8; range 3.8每12.1 years), no contralateral invasive/DCIS occurrence, distant metastasis, or breast cancer每related death were recorded. The 5- and 10-year local recurrence, distant metastasis每free survival, and breast cancer每specific survival were 100%. The 10-year overall survival rate was 90.9%. No late toxicity at 5 and 10 years was recorded. Waiting for pending studies and mature follow-up, we confirmed the efficacy and safety of APBI for low-risk DCIS %K Breast cancer %K radiotherapy %K partial breast irradiation %K ductal carcinoma in situ %K guidelines %U https://journals.sagepub.com/doi/full/10.1177/0300891618811278