%0 Journal Article
%T Repeated Iron¨CSoot Exposure and Nose
%A Dale Uyeminami
%A Emilia A. Laing
%A Janice L. Peake
%A Kent E. Pinkerton
%A Laurie E. Hopkins
%A Savannah M. Mack
%A Suzette Smiley-Jewell
%A Xueting Li
%J Toxicologic Pathology
%@ 1533-1601
%D 2018
%R 10.1177/0192623317729222
%X Particulate exposure has been implicated in the development of a number of neurological maladies such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer¡¯s disease, and idiopathic Parkinson¡¯s disease. Only a few studies have focused on the olfactory pathway as a portal through which combustion-generated particles may enter the brain. The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron¨Csoot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. Adult female C57B6 mice were exposed to iron¨Csoot combustion particles at a concentration of 200 ¦Ìg/m3, which included 40 ¦Ìg/m3 of iron oxide nanoparticles. Mice were exposed for 6 hr/day, 5 days/week for 5 consecutive weeks (25 total exposure days). Our findings visually demonstrate that inhaled ultrafine iron¨Csoot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation
%K nose
%K brain
%K olfactory epithelium
%K ultrafine combustion particles
%K iron/soot
%U https://journals.sagepub.com/doi/full/10.1177/0192623317729222