%0 Journal Article
%T Metabolic cooperation between cancer and non
%A Filipa Lopes-Coelho
%A Jacinta Serpa
%A Sofia Gouveia-Fernandes
%J Tumor Biology
%@ 1423-0380
%D 2018
%R 10.1177/1010428318756203
%X The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors
%K Cancer metabolism
%K microenvironment
%K cancer-associated fibroblasts
%K cancer-associated adipocytes
%K tumor-associated macrophages
%U https://journals.sagepub.com/doi/full/10.1177/1010428318756203