%0 Journal Article
%T Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion
%A Peng-Yu Gong
%A Qing-Guang Wang
%A Teng Jiang
%A Xiao Xue
%A Yang Yang
%A Ying-Dong Zhang
%J Journal of the Renin
%@ 1752-8976
%D 2018
%R 10.1177/1470320318799587
%X This study aimed to evaluate the influence of central angiotensin IV (Ang IV) infusion on chronic cerebral hypoperfusion (CCH)-related neuropathological changes including amyloid-¦Â (A¦Â), hyperphosphorylated tau (p-tau) and the inflammatory response. Rats with CCH received central infusion of Ang IV, its receptor AT4R antagonist divalinal-Ang IV or artificial cerebrospinal fluid for six weeks. During this procedure, the systolic blood pressure (SBP) was monitored, and the levels of A¦Â42, p-tau and pro-inflammatory cytokines in the brain were detected. Rats with CCH exhibited higher levels of A¦Â42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered. This study demonstrates for the first time that Ang IV dose-dependently suppresses inflammation through AT4R in the brains of rats with CCH, which is independent from SBP. These findings suggest that Ang IV/AT4R may represent a potential therapeutic target for CCH-related neurological diseases
%K Angiotensin IV
%K chronic cerebral hypoperfusion
%K inflammation
%K vascular dementia
%K Alzheimer¡¯s disease
%U https://journals.sagepub.com/doi/full/10.1177/1470320318799587