%0 Journal Article
%T Contactin
%A Charlotte E Teunissen
%A Christian Enzinger
%A Franz Fazekas
%A Hugo Vrenken
%A Inge MW Verberk
%A Joep Killestein
%A Madhurima Chatterjee
%A Marleen JA Koel-Simmelink
%A Michael Khalil
%A Stefan Ropele
%J Multiple Sclerosis Journal
%@ 2055-2173
%D 2018
%R 10.1177/2055217318819535
%X Contactin-1 and contactin-2 are important for the maintenance of axonal integrity. To investigate the cerebrospinal fluid levels of contactin-1 and contactin-2 in multiple sclerosis patients and controls, and their potential use as prognostic markers for neurodegeneration. Cerebrospinal fluid contactin-1 and contactin-2 were measured in relapsing¨Cremitting multiple sclerosis (n£¿=£¿41), secondary progressive multiple sclerosis (n£¿=£¿26) and primary progressive multiple sclerosis patients (n£¿=£¿13) and controls (n£¿=£¿18), and in a second cohort with clinically isolated syndrome patients (n£¿=£¿88, median clinical follow-up period of 2.3 years) and controls (n£¿=£¿20). Correlations/linear regressions were analysed with other baseline cerebrospinal fluid axonal damage markers and cross-sectional/longitudinal magnetic resonance imaging features. Contactin-1 and contactin-2 levels were up to 1.4-fold reduced in relapsing¨Cremitting multiple sclerosis (contactin-1: p£¿=£¿0.01, contactin-2: p£¿=£¿0.02) and secondary progressive multiple sclerosis (contactin-1: p£¿=£¿0.05, contactin-2: p£¿=£¿0.02) compared to controls. In clinically isolated syndrome patients, contactin-1 tended to increase when compared to controls (p£¿=£¿0.07). Both contactin-1 and contactin-2 correlated with neurofilament light, neurofilament heavy and magnetic resonance imaging metrics differently depending on the disease stage. In clinically isolated syndrome patients, baseline contactin-2 level (¦Â£¿=£¿¨C0.42, p£¿=£¿0.04) predicted the longitudinal decline in cortex volume. Cerebrospinal fluid contactin-1 and contactin-2 reveal axonal dysfunction in various stages of multiple sclerosis and their inclusion to the biomarker panel may provide better insight into the extent of axonal damage/dysfunction
%K Contactin
%K multiple sclerosis
%K CSF biomarker
%K axonal damage
%K neurofilament
%U https://journals.sagepub.com/doi/full/10.1177/2055217318819535