%0 Journal Article
%T Quassinoids and Alkaloids From the Roots of Eurycoma longifolia
%A Do Thi Ngoc Lan
%A Duong Thu Trang
%A Nguyen Duy Khanh
%A Nguyen Hai Dang
%A Nguyen Quang Trung
%A Nguyen Thi Thu Minh
%A Nguyen Tien Dat
%A Nguyen Tuan Hiep
%A Pham Van Cuong
%A Vu Duc Nam
%J Natural Product Communications
%@ 1555-9475
%D 2019
%R 10.1177/1934578X19850695
%X Five quassinoids and 2 alkaloids were isolated from the roots of Eurycoma longifolia. The structures of 3 new quassinoids, eurycomalide F, G, and H (1-3), were elucidated using a variety of spectroscopic methods. The known compounds were identified as eurycomalide A (4), laurycolactone B (5), 5-methoxycanthin-6-one (6), and canthin-6-one (7). Among the isolated compounds, canthin-6-one (7) exhibited the strongest inhibitory effect on nitric oxide production (IC50 = 16.9 ¦ÌM). 5-Methoxycanthin-6-one (6) and eurycomalide F (1) exhibited weak inhibition with IC50 values of 23.4 and 32.7 ¦ÌM, respectively
%K Eurycoma longifolia
%K Simaroubaceae
%K quassinoid
%K canthin-6-one
%U https://journals.sagepub.com/doi/full/10.1177/1934578X19850695