%0 Journal Article
%T Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
%A Adam Soares
%A Anthony L Traboulsee
%A B Mark Keegan
%A David Clayton
%A Emilie Nevill
%A Erin L MacMillan
%A Hideki Garren
%A Irene M Vavasour
%A Jillian K Chan
%A Lisa Eunyoung Lee
%A Robert L Carruthers
%A Roger Tam
%A Shannon H Kolind
%J Multiple Sclerosis Journal
%@ 2055-2173
%D 2019
%R 10.1177/2055217318824612
%X Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. Case report. Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter
%K Progressive solitary sclerosis
%K multiple sclerosis
%K MRI
%K neuroimaging
%K myelin water imaging
%K demyelination
%U https://journals.sagepub.com/doi/full/10.1177/2055217318824612