%0 Journal Article
%T Abietane Diterpenoids With Potent Cytotoxic Activities From the Resins of Populus euphratica
%A Qian Cao
%A Shao-Xiang Wang
%A Yong-Xian Cheng
%J Natural Product Communications
%@ 1555-9475
%D 2019
%R 10.1177/1934578X19850029
%X A new abietane norditerpenoid, 5-(6-isopropyl-2-methylnaphthalen-1-yl)pentan-2-one (1), with a rare 4,5-seco-19-norabietane skeleton possessing a rearranged angular methyl group at C-5, 2 new naturally occurring compounds, 19-norabieta-4,6,8,11,13-penttaen-3-one (2) and 14-hydroxy-7-oxo ester (3), along with 10 known analogs (4£¿13) were isolated from the resins of Populus euphratica. The new structures were elucidated by spectroscopic analysis (one-/two-dimensional nuclear magnetic resonance and high-reolution electrospray ionization mass spectrometry). Biological evaluation showed that compounds 1 and 2 display low cytotoxicity against normal cells and appreciable cytotoxicity in cancer cells, with 2 to be more sensitive in HepG2 cells with a half-maximal inhibitory concentration value of 27.0 ¦ÌM
%K Populus euphratica
%K Salicaceae
%K resins
%K abietane diterpenoids
%K cytotoxic activities
%U https://journals.sagepub.com/doi/full/10.1177/1934578X19850029