%0 Journal Article
%T Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long
%A Heidi V Russell
%A John Hicks
%A Nino Rainusso
%A Rachel Egler
%A Victor Seghers
%J Pediatric and Developmental Pathology
%@ 1615-5742
%D 2019
%R 10.1177/1093526618822597
%X Children with neuroblastoma rarely present with metastatic disease without identifiable primary tumors. We describe the clinical and histopathologic characteristics of 4 patients aged 1, 7, 7, and 11 years with neuroblastoma involving bone or bone marrow without an apparent primary site. One patient presented with a periorbital bone lesion, 1 presented with a distal femoral lesion, and 2 presented with diffuse bone marrow involvement. All tumors were negative for MYCN amplification. All patients were alive without evidence of disease 5 years after completion of multimodality therapy. Patients with neuroblastoma of the bone and bone marrow without an apparent primary site may constitute a unique group characterized by older age at diagnosis, nonamplified MYCN tumors, and good response to treatment
%K neuroblastoma
%K neural crest tumors
%K surg path
%K imaging studies
%K long-term follow-up
%K without an apparent primary site
%U https://journals.sagepub.com/doi/full/10.1177/1093526618822597