%0 Journal Article
%T Protein S deficiency revealed by skin necrosis in a patient with lupus
%A A Plana-Pla
%A C Ferrandiz Foraster
%A I Bielsa Marsol
%J Lupus
%@ 1477-0962
%D 2019
%R 10.1177/0961203319843345
%X Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had not received warfarin and without APL antibodies who developed extensive skin necrosis due to protein S deficiency. It is important to investigate protein S deficiency in patients with lupus and extensive skin ulcers as it is a sign of arterial thrombosis and venous thromboembolism
%U https://journals.sagepub.com/doi/full/10.1177/0961203319843345