%0 Journal Article
%T Associations between Community
%A David A. Leiman
%A Hui-Jie Lee
%A Nelson Roy
%A Seth M. Cohen
%A Stephanie Misono
%J Otolaryngology每Head and Neck Surgery
%@ 1097-6817
%D 2019
%R 10.1177/0194599818811292
%X To examine the relationship between community-acquired pneumonia (CAP) and proton pump inhibitor (PPI) treatment among patients with laryngeal/voice disorders. Retrospective cohort analysis. Large national administrative US claims database. Patients were included if they were ≡18 years old; had outpatient treatment for a laryngeal/voice disorder from January 1, 2010, to December 31, 2014 (per International Classification of Diseases, Ninth Revision, Clinical Modification codes); had 12 months of continuous enrollment prior to the index date (ie, first diagnosis of laryngeal/voice disorder); had no preindex diagnosis of CAP; and had prescription claims captured from 1 year preindex to end of follow-up. Patient demographics, comorbid conditions, index laryngeal diagnosis, number of unique preindex patient encounters, and CAP diagnoses during the postindex 3 years were collected. Two models〞a time-dependent Cox regression model and a propensity score每based approach with a marginal structural model〞were separately performed for patients with and without pre每index date PPI prescriptions. A total of 392,355 unique patients met inclusion criteria; 188,128 (47.9%) had a PPI prescription. The 3-year absolute risk for CAP was 4.0% and 5.3% among patients without and with preindex PPI use, respectively. For patients without and with pre每index date PPI use, the CAP occurrence for a person who had already received a PPI is 30% to 50% higher, respectively, than for a person who had not yet had a PPI but may receive one later. Patients without and with pre每index date PPI use experienced a roughly 30% to 50% increased likelihood of CAP, respectively, as compared with patients who had not had PPI prescriptions
%K laryngeal disorders
%K voice disorders
%K larynx
%K dysphonia
%K voice
%K proton pump inhibitor
%K adverse event
%K pneumonia
%U https://journals.sagepub.com/doi/full/10.1177/0194599818811292