%0 Journal Article
%T Intravenous radiographic contrast administered prior to high
%A Alia C Lynch
%A Thomas E Schultz
%J Journal of Oncology Pharmacy Practice
%@ 1477-092X
%D 2019
%R 10.1177/1078155218769126
%X Methotrexate is a dihydrofolate reductase inhibitor that interferes with DNA synthesis, DNA repair, and cellular replication. We present the first adult case of a patient who received intravenous contrast prior to administration of high-dose methotrexate, who subsequently experienced delayed methotrexate clearance and renal impairment necessitating the use of glucarpidase. This case displays a possible correlation between intravenous radiographic contrast administration and resulting toxicity due to delayed methotrexate clearance
%K Methotrexate
%K intravenous contrast
%K contrast-induced nephropathy
%K glucarpidase
%K acute kidney injury
%U https://journals.sagepub.com/doi/full/10.1177/1078155218769126