%0 Journal Article %T Intravenous radiographic contrast administered prior to high %A Alia C Lynch %A Thomas E Schultz %J Journal of Oncology Pharmacy Practice %@ 1477-092X %D 2019 %R 10.1177/1078155218769126 %X Methotrexate is a dihydrofolate reductase inhibitor that interferes with DNA synthesis, DNA repair, and cellular replication. We present the first adult case of a patient who received intravenous contrast prior to administration of high-dose methotrexate, who subsequently experienced delayed methotrexate clearance and renal impairment necessitating the use of glucarpidase. This case displays a possible correlation between intravenous radiographic contrast administration and resulting toxicity due to delayed methotrexate clearance %K Methotrexate %K intravenous contrast %K contrast-induced nephropathy %K glucarpidase %K acute kidney injury %U https://journals.sagepub.com/doi/full/10.1177/1078155218769126