%0 Journal Article
%T Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis
%A Bernhard Hemmer
%A Dorothea Buck
%A Gabriele Multhoff
%A Lisa Sick
%A Patricia Lechner
%J Multiple Sclerosis Journal
%@ 2055-2173
%D 2018
%R 10.1177/2055217318767192
%X Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing¨Cremitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS). As controls, serum samples were collected from patients with non-inflammatory neurological diseases (NINDs, n£¿=£¿41), other inflammatory neurological diseases (OINDs, n£¿=£¿28) and healthy donors (HDs, n£¿=£¿114). Serum levels of Hsp70 were quantified using the enzyme-linked immunosorbent assay detecting free and liposomal Hsp70 (lipHsp70 ELISA). Patients with MS displayed significantly higher Hsp70 serum levels than HDs (p£¿<£¿0.001) and significantly lower levels than OINDs (p£¿=£¿0.001). A subgroup analysis revealed that Hsp70 serum levels of CIS/RRMS patients are significantly higher than those of patients with progressive MS (SPMS/PPMS) (p£¿<£¿0.05). Inflammation causes the release of Hsp70 into the blood. As CIS/RRMS are associated with higher Hsp70 serum levels than progressive MS, serum Hsp70 levels might provide a marker for inflammatory processes
%K Multiple sclerosis (MS)
%K inflammation
%K neurodegeneration
%K serum Hsp70
%K lipHsp70 ELISA
%K biomarker
%U https://journals.sagepub.com/doi/full/10.1177/2055217318767192