%0 Journal Article
%T Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
%A Bendik S Winsvold
%A John-Anker Zwart
%A Knut Hagen
%A Sigrid B£¿rte
%A Synne £¿ien Stensland
%J Cephalalgia
%@ 1468-2982
%D 2019
%R 10.1177/0333102419828989
%X Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based setting. We utilized a large, population-based cohort study from Norway, the HUNT Study. Using a cross-sectional design, our sample consisted of 13,731 parents and 8970 offspring. Logistic regression was used to calculate odds ratios with 95% confidence intervals for active migraine and non-migrainous headache in offspring, given active maternal or paternal headache. There was a significant association between maternal migraine and offspring migraine (odds ratio 2.76, 95% confidence interval 2.18¨C3.51). A weaker association (p£¿=£¿0.004 for comparison with maternal migraine) was found between paternal migraine and offspring migraine (odds ratio 1.67, 95% confidence interval 1.33¨C2.28). For non-migrainous headache, there was a significant association between mothers and offspring (odds ratio 1.25, 95% confidence interval 1.10¨C1.43), but not between fathers and offspring. Parental migraine is associated with offspring migraine, with a stronger association for maternal migraine. This may indicate maternal-specific transmission
%K Migraine
%K all headache
%K epidemiology
%U https://journals.sagepub.com/doi/full/10.1177/0333102419828989