%0 Journal Article
%T Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura
%A Hashmat Ghanizada
%A Henrik Winther Schytz
%A Jes Olesen
%A Messoud Ashina
%A Nanna Arngrim
%J Cephalalgia
%@ 1468-2982
%D 2018
%R 10.1177/0333102418765771
%X Carbon monoxide is an endogenously produced signaling gasotransmitter known to cause headache and vasodilation. We hypothesized that inhalation of carbon monoxide would induce migraine-like attacks in migraine without aura patients. In a randomized, double-blind, placebo-controlled crossover design, 12 migraine patients were allocated to inhalation of carbon monoxide (carboxyhemoglobin 22%) or placebo on two separate days. Headache and migraine characteristics were recorded during hospital (0每2 hours) and post-hospital (2每13 hours) phases. Six patients (50%) developed migraine-like attacks after carbon monoxide compared to two after placebo (16.7%) (pˋ=ˋ0.289). The median time to onset of migraine-like attacks after carbon monoxide inhalation was 7.5ˋh (range 3每12) compared to 11.5ˋh (range 11每12) after placebo. Nine out of 12 patients (75%) developed prolonged headache after carbon monoxide. The area under the curve for headache score (0每13 hours) was increased after carbon monoxide compared with placebo (pˋ=ˋ0.033). Carbon monoxide inhalation did not provoke more migraine-like attacks in migraine patients compared to placebo, but induced more headache in patients compared to placebo. These data suggest that non-toxic concentrations of carbon monoxide had low potency in migraine induction and that the carbon monoxide inhalation model is not suitable to study migraine
%K Carbon monoxide
%K gasotransmitter
%K hypoxia
%K nitric oxide
%K migraine
%U https://journals.sagepub.com/doi/full/10.1177/0333102418765771