%0 Journal Article
%T E. coli Bacteremia Strains - High diversity and Associations with Agerelated Clinical Phenomena
%A Dahle UR
%A Melby KK
%A Wester AL
%A Wyller TB
%J Open Journal of Immunology
%D 2014
%R 10.4172/2327-5073.1000140
%X Advanced age is associated with an increased proportion of Escherichia coli in bacteremia as well as an increased risk of death from E. coli blood stream infection. Age-associated differences in normal flora E. coli indicate that elderly persons may be diseased by other groups of E. coli than do younger patients. We studied a historical cohort of 212 patients with community-acquired E. coli bacteremia. The bacterial strains were tested for antimicrobial resistance and analyzed by a generic Multi-Locus Variable-Tandem Repeats Analysis (MLVA). The available 212 strains showed a great diversity, and clustered into ten different MLVA-type complexes (MTC). MTC-b, containing 97 of the strains, was associated with ¡Ý1 comorbid illness (OR 2.02, 95% CI 1.12-3.64), and with to ¡Ý1 atypical symptom (OR 0.46, 95% CI 0.27-0.80). MTC-c, containing 31 strains, was associated with urinary origin of infection (OR 3.28, 95% CI 1.345-8.00) and was preventive against gastrointestinal origin of infection (OR 0.11, 95% CI 0.01-0.83). MTC-g, containing only eight strains, was associated with leukopenia (OR 6.43, 95% CI 1.15-36.00). The strains showed low level of antimicrobial resistance. Fifteen of the 212 patients (7.1%) died within 14 days after admission to hospital. Neither MTC nor antimicrobial resistance was associated with hospital mortality. In conclusion, our study showed a great degree of diversity of the strains and that one of the MTCs was associated with age-related clinical phenomena. None of the MTCs were associated with outcome, indicating that patient characteristics are more important than microbial characteristics
%K Wester AL
%K Melby KK
%K Wyller TB and Dahle UR
%K E. Coli
%K Age
%K Bactermia
%K Genotype
%K Mortality
%U https://www.longdom.org/abstract/e-coli-bacteremia-strains-high-diversity-and-associations-with-agerelated-clinical-phenomena-38974.html