%0 Journal Article
%T Toxic Epidermal Necrolysis: Treatment of Two Cases with Intravenous Immunoglobulin,Sore Mouth Infection
%A Charles Yarbrough
%A Lacey Vence
%J Open Journal of Immunology
%D 2015
%R 10.4172/2155-9554.1000284
%X Toxic epidermal necrolysis (TEN) is a severe allergic reaction, often to drugs, with an approximate 30-40% mortality. Discontinuation of the offending drug and burn unit supportive care are agreed upon as initial therapy. However, use of Intravenous Immunoglobulin (IVIG) has been shown effective but controversial.
We report 2 cases of TEN treated with IVIG for 5 days and burn unit intensive care therapy. One case had early adjunctive systemic corticosteroid therapy; the other case had no systemic steroids. Both cases demonstrated a severity of illness score for TEN (SCORTEN) at day 1 of 35.3% and day 3 of 58.3%.
Previous reports base their opinion regarding IVIG effectiveness on studies that do not uniformly specify these treatment details or wherein IVIG treatment protocol was for less than 5 days. Inclusion of this data and use of this treatment protocol may demonstrate significantly improved outcomes in TEN patients treated with IVIG.
%K Charles Yarbrough and Lacey Vence
%K Toxic epidermal necrolysis
%K Intravenous immunoglobulin
%K Severe allergic reaction
%U https://www.longdom.org/abstract/toxic-epidermal-necrolysis-treatment-of-two-cases-with-intravenous-immunoglobulinsore-mouth-infection-11957.html