%0 Journal Article
%T Serum Transforming Growth Factor andndash; andbeta;1 (TGF- andbeta;1) in Asthmatics: Association between Disease Control, Severity and Duration
%A Alia§× AR Mohamed-Hussein
%A Ebtssam F. Mohammed
%A Hanan O. Mohamed
%A Manal Mohamed Tammam Mahmoud
%A Neveen Abd El-Moneum Hassan
%A Omnia Abd El-Moneum Mohamed
%J Open Journal of Immunology
%D 2015
%R 10.4172/2161-1009.1000200
%X £¿Rationale: Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play
a role. Assessment of airway remodelling by analysis of blood and sputum markers has been developed as non-invasive
procedures to bypass tissue biopsy.
Aim of the work: evaluate the usefulness of estimation of serum TGF-¦Â1, as non- invasive markers of airway
remodelling in patients with bronchial asthma and correlation between its level and degree of asthma control, severity
and duration.
Patients and Methods: the study included 68 asthmatics and 20 controls. They were classified according to level
of control, severity and duration. Blood samples were taken to estimate the serum levels of TGF-¦Â1.
Results: the serum level of TGF-¦Â1 was significantly higher in asthmatics than controls and in patients with
uncontrolled asthma compared to controlled (P<0.001). It was significantly higher in severe and moderate asthma than
with mild asthma (P<0.000) and in patients with disease duration >5 years compared to disease duration <5 years
(P£¿£¿0.001). Significant positive correlation between TGF-¦Â1 and FEV1 (P<0.001) were recorded.
Conclusion: Serum TGF-¦Â1 could be considered as non-invasive markers of airway remodelling, severity of airflow
limitation and as predictor of degree of asthma control
%K Neveen Abd El-Moneum Hassan
%K Alia§× AR Mohamed-Hussein
%K Ebtssam F. Mohammed
%K Omnia Abd El-Moneum Mohamed
%K Hanan O. Mohamed and Manal Mohamed Tammam Mahmoud
%K Serum TGF-¦Â1
%K Growth factor
%K Asthma
%U https://www.longdom.org/abstract/serum-transforming-growth-factor-ndash-embetaem1-tgfem-betaem1-in-asthmatics-association-between-disease-control-severit-34802.html