%0 Journal Article
%T The Contrast of Efficacy and Safety between Carbamazepine and Other Antiepileptic Drugs in Patients with Postencephalitic Epilepsy: Experience from a Developing Country
%A Nong Xiao
%A Wen Feng Song
%A Yang-Mei Chen
%A Ying-Ying Li
%A Zhi-Hui Zhou
%J Open Journal of Immunology
%D 2014
%R 10.4172/2168-975X.1000125
%X Background: Viral encephalitis may cause potentially devastating sequelae, including post-encephalitic epilepsy (PEE) and refractory epilepsy. The purpose of this study was to analyze the efficacy and safety of several antiepileptic drugs (AEDs) in PEE.

Methods: A cohort of patients diagnosed with PEE related to presumed encephalitis was retrospectively studied. Patients were divided into different antiepileptic drug groups. Retention rates, 50% responder rates, remission rates and adverse events were evaluated. Several risk factors for adverse events were assessed, including gender, age and drug choice.

Results: Two hundred and ninety-two patients were enrolled in this study. PEE manifestations occurred mainly in children. Secondary generalized tonic-clonic seizure (SGTCS) was the frequent type in PEE patients. In the first year, in descending order, the retention rates: Carbamazepine (CBZ) > Topiramate(TPM) Phenobarbital(PB) > Sodium Valproate (VPA-Na) Combined > Magnesium Valproate (VPA-Mg) (P < 0.05, CBZ¡¯s was higher than VPAMg¡¯s and Combined therapy¡¯s), the 50% responder rates were: PB > VPA-Mg > VPANa > TPM > CBZ > Combined (P < 0.05, PB¡¯s and VPA-Mg¡¯s are higher than Combined therapy), the remission rates: VPA-Mg > TPM > CBZ > PB > VPA-Na > Phenytoin Sodium (PHT) > Combined (P < 0.05, TPM¡¯s and VPA-Mg¡¯s are higher than combined therapy¡¯s). In decreasing order, the rates for serious adverse effects were: PHT > TPM > CBZ > PB > VPA-Na > Combined > VPA-Mg.

Conclusions: Considering the retention rates, remission rates, 50% responder rates and adverse effects together, we suggest that, compared to CBZ, TPM and VPA-Na should be the good alternatives for PEE patients. When considering the cost together, PB should be another choice in PEE. It is worthy to enlarge the sample size of VPA-Mg to further confirm its good efficacy and safety. And PHT was not recommended for PEE patients.
%K Ying-Ying Li
%K Zhi-Hui Zhou
%K Nong Xiao
%K Yang-Mei Chen and Wen Feng Song
%K Epilepsy
%K Postencephalitic epilepsy
%K Efficacy
%K Safety
%K Antiepileptic drugs
%U https://www.longdom.org/abstract/the-contrast-of-efficacy-and-safety-between-carbamazepine-and-other-antiepileptic-drugs-in-patients-with-postencephaliti-21066.html