%0 Journal Article
%T Immune Response Modulation by Tumor-Secreted Glycosphingolipids
%A Delphine J Lee
%A Ingrid Cely
%A Peter A Sieling
%A Ricardo D Lardone
%A null
%J Open Journal of Immunology
%D 2014
%R 10.4172/2168-958X.1000107
%X Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) are now recognized as having critical effects on cellular physiology, including proliferation, differentiation, viral transformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL composition compared to parental normal cells. These modifications may contribute to both tumor survival and exert striking effects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.
%K Ricardo D Lardone
%K Ingrid Cely
%K Peter A Sieling
%K and Delphine J Lee
%K Glycosphingolipids
%K Anti-tumor immunity
%K Cancer
%U https://www.longdom.org/abstract/immune-response-modulation-by-tumorsecreted-glycosphingolipids-9931.html