%0 Journal Article
%T Molar Concentration Welcomes Avogadro in Postgenomic Analytics
%A Alex
%A Andrey V Lisitsa
%A Ekaterina V Poverennaya
%A Elena A Ponomarenko
%A Olga I Kiseleva
%A er I Archakov

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%J Open Journal of Immunology
%D -1
%R 10.4172/2161-1009.1000216
%X The researchers working with high-throughput methods of genomics, transcriptomics, and proteomics reconsider the concept of concentration and evaluate the data obtained in the number of copies of biomacromolecules. Measurement of copy number reflects a steady trend in increasing the sensitivity of postgenomic analytical methods, up to the level of a single molecule. In this paper we review the physical meaning of the terms "molar concentration" and "Avogadro¡¯s number" to establish a relationship between them. The relationship between the molar concentration and the number of copies of that same macromolecule in a certain volume is set through the reverse Avogadro¡¯s number, the value of which (10-24 D£¿) characterizes the molar concentration of a single molecule in 1 liter. Using the reverse Avogadro¡¯s number, we deal with situations in analyzing homogeneous biological solutions and heterogeneous cellular material.
%K Andrey V Lisitsa
%K Elena A Ponomarenko
%K Olga I Kiseleva
%K Ekaterina V Poverennaya and Alexander I Archakov

£¿
%K Avogadro¡¯s number
%K Protein copy number
%K Blood plasma
%K Cell line
%U https://www.longdom.org/abstract/molar-concentration-welcomes-avogadro-in-postgenomic-analytics-34976.html