%0 Journal Article
%T Topical Delivery of Lipid Based Amphotericin B Gel in the Treatment of Fungal Infection: A Clinical Efficacy, Safety and Tolerability Study in Patients
%A Ateeq Ahmad
%A Bhavik A Bhavsar
%A Hanmant Barkate
%A Imran Ahmad
%A Jayaraman AM
%A Kalpesh Shah
%A Mahesh Paithankar
%A Manish Sharma
%A Radha KR
%A Ranjan C Raval
%A Saifuddin Sheikh
%A Shoukath M Ali
%J Open Journal of Immunology
%D 2014
%R 10.4172/2155-9554.1000248
%X Objectives: A novel topical formulation of lipid based amphotericin B (0.1% amphotericin B Gel) was developed to assess the safety, tolerability and efficacy in adult patients with cutaneous and/or mucocutaneous fungal infection.

Methods: Amphotericin B gel was formulated using lipids. In vitro release assay of amphotericin B was measured using paddle apparatus maintained at 37.0¡ã ¡À 0.5¡ãC. The stability studies of amphotericin B gel were carried out at 2-8¡ãC, 25¡ãC and 40¡ãC. To test the effect of the drug in clinical setting, 100 patients with recurrent case after failure to standard therapy for cutaneous and/or mucocutaneous fungal infection were treated with amphotericin B Gel. The amphotericin B Gel was applied on the affected area twice daily for 14 days in patients with cutaneous fungal infection and for 7 days in patients of mucocutaneous fungal infection. Response to the amphotericin B Gel treatment was monitored in the patients for up to 14 days and 28 days for mucocutaneous and cutaneous infection respectively.

Results: Based on the stability studies, the recommended shelf life of amphotericin B gel is 24 months at 25¡ãC. In vitro studies showed the release of ~90% amphotericin B within two hours and complete release within four hours. A total of 83 patients were assessed for cutaneous fungal infection where 39 patients were cured, 9 patients showed marked improvement, 26 patients showed moderate improvement and 9 patients showed failure after the treatment. For mucocutaneous fungal infection, 100% patients were cured at the end of the treatment. No serious adverse events were reported in patients during the study.

Conclusion: Lipid based amphotericin B gel in patients with cutaneous and mucocutaneous fungal infections was found to be safe, tolerable and efficacious.
%K Saifuddin Sheikh
%K Ateeq Ahmad
%K Shoukath M Ali
%K Mahesh Paithankar
%K Hanmant Barkate
%K Ranjan C Raval
%K Kalpesh Shah
%K Bhavik A Bhavsar
%K Radha KR
%K Jayaraman AM
%K Manish Sharma and Imran Ahmad
%K Amphotericin B Gel
%K Topical
%K Efficacy
%K Fungal infection
%U https://www.longdom.org/abstract/topical-delivery-of-lipid-based-amphotericin-b-gel-in-the-treatment-of-fungal-infection-a-clinical-efficacy-safety-and-t-10701.html