%0 Journal Article
%T Intake of the First-Generation Anti-Histamines in Early Childhood May Have an Adverse Effect on Cognitive Function. Population Based Pharmacoepidemiologic Study in Non-Asthamtic Children
%A Agata Sowa
%A Elzbieta Mroz
%A El£¿bieta Flak
%A Maria Butscher
%A Wieslaw A Jedrychowski
%J Open Journal of Immunology
%D 2013
%R 10.4172/2167-1052.1000138
%X As the allergic diseases increase steadily worldwide, the main goal of the study was to assess the association between the early intake of the first-generation sedative antihistamines in young non-asthmatic children and their cognitive function at the age of 7. The size of the exposure effect was measured by the Wechsler intelligence Scale for Children (WISC-R) and adjusted in multivariable models for major confounders known to be important for children cognitive development. The study included 212 children who were non-asthmatic and completed the monitoring of antihistamines intake over 3 years preceding the WISC-R intelligence testing. While the first-generation drugs were used by 36.7% children and the newer generation by 39.6%, both categories of drugs were taken by 17.8% children. The analysis showed the deficit of 12 points on the verbal WISC-R IQ scale only in children who used the first- generation antihistamines for a longer time (beta coeff.=-11.7, 95% CI: -19.6, -3.7) compared to non-users. Out of the covariates included in the multivariable regression models, maternal education (beta coeff.=0.92, 95% CI: 0.37, 1.46) and breastfeeding at least for 6 months (beta coeff.=3.29; 95% CI: 0.34, 6.23) showed a significant positive impact on the verbal IQ. Intake of the newer generation antihistamines were associated neither with verbal nor performance IQ scores. Concluding, the results suggest that the ¡°sedative antihistamines¡± have a negative impact on the verbal but not performance IQs of young children if drugs were used over a longer period. The weaker verbal communication ability of young children may hinder the cognitive development of children and be associated with relatively poor school academic achievement
%K Wieslaw A Jedrychowski
%K El£¿bieta Flak
%K Elzbieta Mroz
%K Maria Butscher and Agata Sowa
%K Epidemiologic study
%K Children
%K Antihistamines
%K Cognitive function
%U https://www.longdom.org/abstract/intake-of-the-firstgeneration-antihistamines-in-early-childhood-may-have-an-adverse-effect-on-cognitive-function-populat-7816.html