%0 Journal Article
%T Possible Dual Immunoreactivity for Laminin-332 and Type VII Collagen in a Case with Vancomycin-Induced Linear Iga Bullous Dermatosis Manifesting as Erythroderma
%A Minoru Yoneda
%A Noritaka Oyama
%A Taeko Nakamura-Wakatsuki
%A Toshiyuki Yamamoto
%A Yuko Asoh
%J Open Journal of Immunology
%D 2012
%R 10.4172/2155-9554.1000151
%X We report a unique case of vancomycin-induced linear IgA bullous dermatosis (LABD) presenting as erythroderma. Direct immunofluorescence showed a linear IgA deposition at the dermal side of the basement membrane zone (BMZ), and double immunostaining using patients¡¯ skin as a substrate revealed that the in vivo IgA signal co-localized with laminin-332 and type VII collagen. Our case is the first documentation of vancomycin-induced LABD, in which the pathogenic IgA deposit would concomitantly recognize the two distinct antigens at the dermal BMZ.
%K Yuko Asoh
%K Noritaka Oyama
%K Taeko Nakamura-Wakatsuki
%K Toshiyuki Yamamoto and Minoru Yoneda
%K Linear Iga bullous dermatosis
%K Erythroderma
%K Vancomycin
%K Laminin-332
%K Type VII collagen
%U https://www.longdom.org/abstract/possible-dual-immunoreactivity-for-laminin332-and-type-vii-collagen-in-a-case-with-vancomycininduced-linear-iga-bullous--6682.html