%0 Journal Article
%T Gd3+-Anionic Linear Globular Dendrimer-G2-C595 A Dual Novel Nanoprobe for MR Imaging and Therapeutic Agent: An In Vitro Study
%A Alireza Khatami
%A Daryoush Shahbazi-Gahrouei
%A Mehdi Mirzaei
%A Mohammadali Mohagheghi
%J Open Journal of Immunology
%D 2012
%R 10.4172/2167-7956.1000103
%X Early cancer detection using MR imaging is of high global interest as a powerful non-invasive modality. The aim of this study was to synthesize a nano-dendrimer and its conjugate with C595 mab against breast cancer cell, followed by its chelating with Gd3+. At the end, its ability as a nanosized probe for detection of breast cancer cells was investigated. For this reason, anti-MUC-1 mab C595 was coupled to a biocompatible anionic linear globular dendrimer G2 (ALGDG2) (Poly Ethylene Glycol PEG core and citric acid shell) followed by loading with Gd3+. MR imaging parameters of the prepared nanoconjugate was investigated in vitro performing several studies such as 1H-NMR and 17O-NMR, MUC-1 antigen. The obtained data showed a powerful relaxations as well as selective MUC-1 antigen and cell binding. Findings of this study showed that Gd3+-ALGDG2-C595 nano-probe is potentially, a selective breast molecular imaging agent
%K Mehdi Mirzaei
%K Mohammadali Mohagheghi
%K Daryoush Shahbazi-Gahrouei and Alireza Khatami
%K MR imaging
%K Anionic linear glubolar dendrimer
%K C595
%K MUC-1
%K Breast cancer detection
%U https://www.longdom.org/abstract/gdsup3supanionic-linear-globular-dendrimergsub2subc595-a-dual-novel-nanoprobe-for-mr-imaging-and-therapeutic-agent-anem--19689.html