%0 Journal Article
%T Progress in HIV-Carbohydrate Interactions: Infectivity of CCR5-Tropic HIV-1 is Enhanced by GP120 from CXCR4-Tropic Virus
%A Hauser H
%A Schreiber M
%A Schwalbe B
%J Open Journal of Immunology
%D 2014
%R 10.4172/2168-958X.1000110
%X Human immunodeficiency virus type-1 is highly variable and utilizes two independent pathways, one via the CCR5 coreceptor and the other via CXCR4 to enter CD4+ cells. Both virus types can simultaneously be found in HIV-1-infected patients and the shift to a majority of CXCR4-tropic viruses is an indication for the development of AIDS-related symptoms. It is thought that each virus type will infect cells independently using its specific coreceptor pathways. In this short communication we demonstrate that CCR5-tropic HIV-1 is enhanced by the envelope from CXCR4-tropic viruses. This cross-enhancing effect was completely suppressed when the target cells were pretreated with hexadimethrine bromide, suggesting that carbohydrate structures on the cellular membrane play an important role for envelope-dependent enhancement of viral entry
%K Schwalbe B
%K Hauser H and Schreiber M
%K HIV-1
%K V3 loop
%K Coreceptor tropism
%K N-glycosylation
%K Viral entry efficiency
%U https://www.longdom.org/abstract/progress-in-hivcarbohydrate-interactions-infectivity-of-ccr5tropic-hiv1-is-enhanced-by-gp120-from-cxcr4tropic-virus-10666.html