%0 Journal Article
%T Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis
%A Raghavan PR
%J Open Journal of Immunology
%D 2017
%R 10.4172/2155-9554.1000433
%X Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn¡¯s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune systemsuppressing medications such as methotrexate.
The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab£¿ targeting TNF-¦Á for the treatment of psoriasis. Other FDA approved drugs are Tremfya£¿ targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz£¿ that blocks IL17 for treatment of plaque psoriasis.
Metadichol£¿ a nanoformulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of ROR¦Ãt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol£¿ has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.
%K Raghavan PR
%K Metadichol
%K psoriasis
%K Nuclear receptors
%K Atopic dermatitis
%K VDR
%K AHR
%K TNF alpha
%K ICAM1
%K Vitamin D
%K Calcitriol
%K Inverse agonist
%K RORC
%K Retinoic acid-related nuclear receptor gamma
%K IL17
%K IL22
%K IL23
%K Th17
%K Th1
%K TH2
%K Long chain alcohols
%U https://www.longdom.org/abstract/metadichol-a-novel-ror-gamma-inverse-agonist-and-its-applications-in-psoriasis-16749.html