%0 Journal Article
%T The Efficacy and Safety of Sterile Graded Talc in Pleurodesis for Malignant
Pleural Effusion: Phase II Study
%A Akiko Saito
%A Atsuko Ishida
%A Chiyoe Kitagawa
%A Hideo Saka
%A Kazuhiko Nakagawa
%A Koji Takeda
%A Masahide Oki
%A Shinji Sasada
%A Shunichi Negoro
%A Terunao Miyazawa
%A Yoshihito Kogure
%A Yuki Kojima
%J Open Journal of Immunology
%D 2016
%R 10.4172/2167-0870.1000279
%X Objective: Introduction of NPC-05 (sterile graded talc) into Japanese clinical practice is expected to lead to persistent prevention of re-accumulation of MPE and alleviation of concomitant symptoms in patients, including dyspnea and chest pain. We conduct an investigator-initiated trial in Japan to clarify the efficacy and safety of NPC-05 for use as a pleurodesis agent.  Methods: This study is a multicenter uncontrolled open-label phase II study. An uncontrolled open-label joint clinical study is conducted in 6 institutes, involving 30 patients with MPE.  Conclusion: Sterile graded talc has been described as the most useful pleurodesis drug for treating malignant pleural effusion in many guidelines and meta-analyses; thus, it is used as a standard pleurodesis agent in Western countries. However, its efficacy and safety have not been examined in Japan.  This study assessed the efficacy and safety of NC-05, sterile graded talc, in 30 Japanese patients with malignant pleural effusion
%K Hideo Saka
%K Masahide Oki
%K Chiyoe Kitagawa
%K Yoshihito Kogure
%K Yuki Kojima
%K Akiko Saito
%K Atsuko Ishida
%K Terunao Miyazawa
%K Koji Takeda
%K Kazuhiko Nakagawa
%K Shinji Sasada and Shunichi Negoro
%K Sterile graded talc
%K Pleurodesis
%K Malignant pleural effusion
%K Efficacy
%K Safety
%U https://www.longdom.org/abstract/the-efficacy-and-safety-of-sterile-graded-talc-in-pleurodesis-for-malignantpleural-effusion-phase-ii-study-51386.html