%0 Journal Article
%T The influence of liver fat deposition on the quantification of the liver-iron fraction using fast-kilovolt-peak switching dual-energy CT imaging and material decomposition technique: an  in vitro  experimental study
%A Guanxun Cheng
%A Guanyong He
%A Qiao Shi
%A Tingting Xie
%A Yongbin Li
%A Zhen Zhang
%J SCIE-indexed Journal
%D 2019
%X Hepatic iron overload usually occurs in patients with hereditary hemochromatosis, which often results in an increase of CT values in liver parenchyma (1). The presence of iron overload is diagnosed when the CT value of the liver is greater than 75 HU on non-contrast enhanced CT (2). However, the increase of CT value cannot fully reflect the existence and severity of hepatic iron deposition, which might be susceptible to fatty degeneration, glycogen deposition, anemia, and other factors. As a result, the degree of liver iron overload has been underestimated (3,4). The material decomposition (MD) technique in dual-energy spectral (DESCT) is one of the noninvasive imaging methods to evaluate iron overload in the liver. Severity of iron overload and the diagnosis of iron overload in patients with long-term blood transfusions can be assessed to guide the treatment of iron removal and evaluate the treatment effect (5,6)
%U http://qims.amegroups.com/article/view/25303/23667