%0 Journal Article %T Renal cell carcinoma: preoperative evaluate the grade of histological malignancy using volumetric histogram analysis derived from magnetic resonance diffusion kurtosis imaging %A Guangyao Wu %A Jingyun Cheng %A Ke Wang %A Yan Wang %J SCIE-indexed Journal %D 2019 %X Renal cell carcinoma (RCC) is the most common pathological type of kidney cancer. Its global morbidity and mortality increased at a rate of about 2¨C3% per decade (1). Histologic grade of RCC affects both patient¡¯s prognosis and surgical planning. Consequently, an accurate preoperative assessment is essential (2,3). Histologic grade is mainly based on the Fuhrman classification system, which requires a needle biopsy or postoperative pathological examination. However, a biopsy is inherently invasive with multiple possible complications. Problems such as sampling errors and observer variability limit its application (4,5). Therefore, there is a need to develop non-invasive preoperative assessment methods %U http://qims.amegroups.com/article/view/25379/23670