%0 Journal Article %T Improving medical care and prevention in adults with congenital heart disease¡ªreflections on a global problem¡ªpart II: infective endocarditis, pulmonary hypertension, pulmonary arterial hypertension and aortopathy %A Christian Schlensak %A David Celermajer %A David Pittrow %A Dirk Lossnitzer %A Erwin Oechslin %A Fokko de Haan %A Hans-Carlo Kallfelz %A Harald Kaemmerer %A Jamil Aboulhosn %A Joerg Schelling %A Koichiro Niwa %A Lars Pieper %A Linda Sanftenberg %A Michael Weyand %A Nicole Nagdyman %A Oeztekin Oto %A Peter Ewert %A Renate Oberhoffer %A Rhoia Neidenbach %A Stephan Achenbach %A Thomas Meinertz %A Ulrike M. M. Bauer %A Yskert von Kodolitsch %J SCIE-indexed Journal %D 2018 %X The exact percentage of IE in the general population is unknown. A scientific statement for healthcare professionals from the American Heart Association quotes an annual incidence ranging from 3¨C7 per 100,000 person-years in the most contemporary population surveys (1-4). The wide range of incidence rates, reported from 1¨C15 cases per 100,000 per year, vary due to different inclusion data. They result from inclusion of different populations at risk, diverse diagnostic criteria and inclusion of cases with ¡°possible¡± IE and referral bias (5-8). Epidemiological studies on IE from hospital case series suffer from selection bias, while well conducted prospective studies from population-based investigations are scarce (6). Amongst adults with CHD the incidence of IE remains according to contemporary reports between 0.91 and 1.32 cases/1,000 patient-years (9,10) %U http://cdt.amegroups.com/article/view/23025/22177