%0 Journal Article
%T The efficacy of glycemic control with continuous glucose monitoring on atheroma progression: rationale and design of the Observation of Coronary Atheroma Progression under Continuous Glucose Monitoring Guidance in Patients with Type 2 Diabetes Mellitus (OPTIMAL)
%A Cheol Son
%A Hisashi Makino
%A Kiminori Hosoda
%A Kunihiro Nishimura
%A Kyoko Honda-Kohmo
%A Masaki Matsubara
%A Michio Noguchi
%A Miki Matsuo
%A Ryo Koezuka
%A Satoshi Yasuda
%A Tamiko Tamanaha
%A Teruo Noguchi
%A Tsutomu Tomita
%A Yasuhide Asaumi
%A Yoko Ohata
%A Yoshihiro Miyamoto
%A Yu Kataoka
%J SCIE-indexed Journal
%D 2019
%X Current therapeutic guidelines recommend achieving glycated hemoglobin HbA1c <7.0% to prevent macrovascular diseases in type 2 diabetes mellitus (T2DM) patients (1,2). However, several randomized controlled trials demonstrated that stricter control of HbA1c did not necessarily improve their cardiovascular outcomes (3-5). In particular, intensive lowering HbA1c elevates a risk of hypoglycemia which has been shown to associate with higher mortality (5). These observations suggest the limitation of HbA1c-based glycemic control for the prevention of diabetic macrovascular diseases. Given that HbA1c reflects average blood glucose in the past 1¨C2 months but not serial changes in glucose level including hypoglycemia, the another approach enabling real-time accurate monitoring of glucose level is required
%U http://cdt.amegroups.com/article/view/29691/26109