%0 Journal Article
%T Niemann-Pick disease treatment: a systematic review of clinical trials
%A Alejandro Lucia
%A Alejandro Santos-Lozano
%A Carmen Fiuza-Luces
%A Diana Villamandos Garc¨Şa
%A Fabian Sanchis-Gomar
%A Gisela Nogales Gadea
%A Helios Pareja-Galeano
%A Nuria Garatachea
%J SCIE-indexed Journal
%D 2015
%R 10.3978/j.issn.2305-5839.2015.12.04
%X Niemann-Pick (NP) disease is caused by an abnormality in lysosomes, which are unable to degrade macromolecules; as a result, the latter accumulate inside these organelles to form cellular inclusions (1-3). NP disease encompasses a set of autosomal recessive hereditary abnormalities (1) characterized by the accumulation of lipids, mostly sphingomyelin and cholesterol, in different organs such as spleen or liver (1,4,5)
%U http://atm.amegroups.com/article/view/8611/9338