%0 Journal Article
%T Conservative mastectomies for breast cancer and risk-reducing surgery: the Memorial Sloan Kettering Cancer Center experience
%A Aidan T. Manning
%A Virgilio S. Sacchini
%J SCIE-indexed Journal
%D 2016
%X The surgical management of breast cancer has changed significantly in recent decades, from the disfiguring radical mastectomy, commonly performed until the mid 1970s, to breast-conserving surgery and sentinel lymph node biopsy, in which minimal breast tissue is removed and the morbidity associated with more extensive axillary surgery is avoided. There are, however, several circumstances in which mastectomy is still indicated, such as multicentric disease and inflammatory breast cancer (IBC), and circumstances in which breast radiation is contraindicated (such as pregnancy, previous breast-conserving therapy, and connective tissue diseases). In addition, some women diagnosed with breast cancer will choose mastectomy as their treatment of choice, even when breast conservation is possible, often undergoing a contralateral prophylactic mastectomy (CPM) at the same time (1). Risk-reducing surgery is also commonly performed in high-risk patients, such as those with a genetic predisposition to breast cancer and¡ªin particular¡ªthose carrying a germline BRCA1 or BRCA2 mutation (2)
%U http://gs.amegroups.com/article/view/8143/9418