%0 Journal Article
%T The effect of red blood cell transfusion on plasma hepcidin and growth differentiation factor 15 in gastric cancer patients: a prospective study
%A Jingfu Liu
%A Shan Chen
%A Xianren Ye
%J SCIE-indexed Journal
%D 2019
%R 10.21037/atm.2019.08.33
%X The incidence and mortality of gastric cancer are the second highest among malignant tumors in China (1). Anemia is one of the most common complications in gastric cancer. In 2012, a survey from China reported that the highest incidence (66.99%) of anemia was observed in upper gastrointestinal cancer patients among multiple solid cancers. Anemia is indicated to be associated with a reduction of the quality of life (2-4) and to be an adverse factor for treatment outcomes and long-term prognosis (5,6) in cancer patients. Red blood cell (RBC) transfusion is an option of treatment for anemia, especially for patients who need rapid improvement in hemoglobin level. However, RBC transfusion not only can transmit infectious disease but can also adversely impact post-operation complications (7,8), cancer recurrence, and survival (9-12). The exact mechanism is still unclear, as most studies about the mechanism are focused on transfusion-related immunomodulation
%U http://atm.amegroups.com/article/view/28741/html