%0 Journal Article
%T The proportion of CD19 + CD24 hi CD27 +  regulatory B cells predicts the occurrence of acute allograft rejection in liver transplantation
%A Feng Zhan
%A Guwei Ji
%A Haoming Zhou
%A Hui Zhang
%A Ji Gao
%A Jian Gu
%A Jianhua Rao
%A Ling Lu
%A Xiaoxin Mu
%A Xuhao Ni
%A Yongxiang Xia
%J SCIE-indexed Journal
%D 2019
%R 10.21037/atm.2019.08.05
%X Acute allograft rejection (AR) still remains a major cause of early allograft loss and an obstacle for long-term allograft survival after liver transplantation, despite the usage of modern immunosuppressive agents. Thus, the early diagnosis and treatment of AR are very important for patients undergoing transplantation. Although the percutaneous liver biopsy is currently preferred as the gold standard diagnosis for AR, still it is an invasive tool with a risk of related complications post biopsy. Despite the increasing interest in the study of potential biomarkers and risk factors for AR, few of these factors are used routinely in clinical practice (1-3). Currently, the immunological monitoring after liver transplantation relies completely on clinical evaluation and the measurement of serum immunosuppressant levels. Pro-inflammatory and immunoregulatory cytokines are the most studied biomarkers of AR (4). However, many of these cytokines are unable to differentiate between AR and infections
%U http://atm.amegroups.com/article/view/29020/html