%0 Journal Article
%T Prospects to translate the biology of IL-33 and ST2 during organ transplantation into therapeutics to treat graft-versus-host disease
%A E. Suzanne Cohen
%A Ian C. Scott
%A Kirsty F. Houslay
%J SCIE-indexed Journal
%D 2016
%R 10.21037/atm.2016.11.74
%X Interleukin (IL)-33 (also known as IL1F11, NF-HEV) is an IL-1 family cytokine constitutively expressed at endothelial and epithelial barrier surfaces where it is rapidly released from cells during tissue injury (1). IL-33 signals via a receptor complex of ST2 (serum stimulation 2; also known as IL1RL1, DER4, FIT-1, T1, IL33R) and IL-1 receptor accessory protein to initiate and amplify inflammatory responses through activation of NF¦ĘB and MAP Kinase signalling pathways (1,2). Due to its rapid action following injury or infection, IL-33 is often referred to as an ˇ°alarminˇ± or endogenous danger signal
%U http://atm.amegroups.com/article/view/13004/html